Gene information
Official symbol FURIN
Official full name furin, paired basic amino acid cleaving enzyme
Gene type protein-coding gene
Chromosome15q26.1
Alias symbolSPC1
Previous symbolPCSK3|FUR|PACE
Gene familyProprotein convertase subtilisin/kexin family
Resources
Entrez Gene 5045
HGNC HGNC:8568
Ensembl ENSG00000140564
Vega OTTHUMG00000149831
UCSC uc002bpu.2
GO terms: 83 records
GO Description Category LogP Number of genes Detail
GO:0001701 in utero embryonic development GO Biological Processes -8.76987260 44 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002861 regulation of inflammatory response to antigenic stimulus GO Biological Processes -5.72585157 11 More
GO:0002862 negative regulation of inflammatory response to antigenic stimulus GO Biological Processes -3.60825621 7 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004867 serine-type endopeptidase inhibitor activity GO Molecular Functions -8.20238048 12 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005796 Golgi lumen GO Cellular Components -14.6918478 18 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -8.77828157 29 More
GO:0007179 transforming growth factor beta receptor signaling pathway GO Biological Processes -7.95704539 19 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0016486 peptide hormone processing GO Biological Processes -7.86007212 8 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031638 zymogen activation GO Biological Processes -13.0866363 13 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032371 regulation of sterol transport GO Biological Processes -19.2332049 29 More
GO:0032374 regulation of cholesterol transport GO Biological Processes -19.2332049 29 More
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process GO Biological Processes -4.36511543 3 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042177 negative regulation of protein catabolic process GO Biological Processes -5.18322511 10 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0051043 regulation of membrane protein ectodomain proteolysis GO Biological Processes -16.3022563 12 More
GO:0051044 positive regulation of membrane protein ectodomain proteolysis GO Biological Processes -9.19233133 7 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071559 response to transforming growth factor beta GO Biological Processes -17.0634996 37 More
GO:0071560 cellular response to transforming growth factor beta stimulus GO Biological Processes -16.8909657 36 More
GO:0071634 regulation of transforming growth factor beta production GO Biological Processes -6.40741477 11 More
GO:0097435 supramolecular fiber organization GO Biological Processes -6.48496756 24 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:0140448 signaling receptor ligand precursor processing GO Biological Processes -9.03552172 9 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1990000 amyloid fibril formation GO Biological Processes -2.73474492 3 More
GO:2000644 regulation of receptor catabolic process GO Biological Processes -3.46984057 3 More
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
furin proteomics recurrent myocardial infarction[prognosis (bad)] acute myocardial infarction Wang YK et al. Metabolism. 2020
furin proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Wang YK et al. Metabolism. 2020
furin proteomics death[prognosis (bad)] acute myocardial infarction Wang YK et al. Metabolism. 2020
furin proteomics heart failure hospitalization[prognosis (bad)] acute myocardial infarction Wang YK et al. Metabolism. 2020
furin proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Wang YK et al. Metabolism. 2020
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